公立大学法人大阪市立大学
Facebook Twitter Instagram YouTube
Personal tools
公立大学法人大阪市立大学
News

Development of new antibody for treatment of Alzheimer’s disease

Published on Jan 09, 2015

Research

The research results below were reported in the following media: (*=online edition)
◆9 January JiJi Press Ltd.*, The Sankei Shimbun*, Kyodo News*,
    NHK Newsterrace Kansai, Kansai 845, Newswatch 9, BS News
    Kansai Telecasting Corporation News Japan
◆10 January Nihon Keizai Shimbun, Yomiuri Shimbun, Mainichi Shimbun
◆12 January Chinanews*
◆15 January Nikkan Kogyo Shimbun (Business & Technology Daily News)
◆5 February Asahi Shimbun
+ a large number of local newspapers?

Outline

The research group of Associate Professor Takami Tomiyama of the Osaka City University Graduate School of Medicine Department of Neuroscience has developed a new monoclonal antibody for the treatment of Alzheimer’s disease. In the brain of patients with Alzheimer ’s disease two pathological changes appear: senile plaques caused by the buildup of amyloid β peptide outside cells and neurofibrillary tangles caused by the buildup of hyperphosphorylated tau proteins within cells.

Until now most research to develop medicines has focused on the amyloid β peptide, but so far none of them has shown effectiveness in clinical trials. This research instead developed a new monoclonal antibody that binds with the phosphorylated tau proteins to eliminate them. In the future, medical treatment for Alzheimer’s disease will most likely consist of a combination of medicines aimed at amyloid β peptides and medicines focusing on phosphorylated tau proteins. The antibody developed in this research is a promising prototype for a medicine aimed at phosphorylated tau proteins as it significantly reduced tau pathologies including neurofibrillary tangles and improved memory in aged model mice.

The research article was published in the online-edition of the Annals of Clinical and Translational Neurology of the American Neurological Association on 9 January 2015, 15:00 Japanese time.

【Journal name】Annals of Clinical and Translational Neurology
【Article Title】Passive immunotherapy of tauopathy targeting pSer413-tau:
a pilot study in mice
【Authors】Tomohiro Umeda, Hiroshi Eguchi, Yuichi Kunori, Yoichi Matsumoto, Taizo Taniguchi, Hiroshi Mori, Takami Tomiyama
【URL】http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2328-9503

このカテゴリー内のナビゲーション